Season Two premiered on September 24, 2015, and concluded on March 17, 2016. The full-disc DVD/Blu-ray set of Season One has not yet been released.
Annalise Keating is a prominent criminal defense attorney and a law professor at Middleton University in Philadelphia. She selects five students to intern at her firm: Wes Gibbins, Connor Walsh, Michaela Pratt, Asher Millstone, and Laurel Castillo. They work with Annalise's employees, Frank Delfino and Bonnie Winterbottom, an associate lawyer. As Season 1 introduces occasional clients for Keating, it explores two related murders through both flashback and flashforward sequences: Lila Stangard, mistress of Annalise's husband Sam Keating and a student at Middleton; and then Sam Keating at the hands of Annalise's interns.
The first nine episodes alternate between the present-day timeline in medias res, depicting Wes, Connor, Michaela, and Laurel covering up Sam's murder by disposing of his body, and the flashbacks detailing the course of events leading up to Sam's death: Annalise becomes involved in the Lila Stangard investigation at Wes' urging, leading her to discover Sam's affair and creating suspicion that he killed Lila. The final six episodes explore Annalise's attempt to help her interns cover up Sam's murder and legally implicate Sam in Lila's death, and flashbacks to Lila's final moments before her murder.
- The title of every episode is part of the dialogue from the respective episode.
- Annalise's classroom in the pilot is an auditorium at Ursinus University in Pennsylvania. After filming the pilot, it was recreated as a set.